Ma ka olelo anaberberine , ʻaʻole ʻike iki nā mea a pau, akā pono nā mea a pau e ʻike i kahi ʻōlelo kamaʻāina: ʻAi ke kanaka leo i ka coptis - ʻaʻole hiki iā ia ke haʻi i ka ʻeha! Pololei, ʻo ka mea ʻawaʻawa nui o ka coptis he berberine, ʻo ia ka berberine hydrochloride.
ʻO Berberine (BBR) kahi alkaloid isoquinoline - C20H19NO5 i unuhi ʻia mai Coptis chinensis. Aia i loko o nā mea kanu o 10 genera a me 4 ʻohana me ka Berberidaceae. Hiki ke hoʻoheheʻe ʻia nā kristal like ʻole melemele mai diethyl ether, me kahi helu heheʻe o 145°C. Hiki ke hoʻoheheʻe ʻia i ka wai a hiki ʻole ke hoʻoheheʻe ʻia i loko o benzene, diethyl ether a me chloroform.
Ua hōʻoia ka noiʻi lāʻau lapaʻau hou i ka berberine he koʻikoʻi ka puʻuwai anti-naʻau, anti-arrhythmia, hoʻohaʻahaʻa i ka cholesterol, anti-vascular smooth muscle proliferation, hoʻomaikaʻi i ka insulin resistance, anti-platelet, anti-inflammatory a me nā hopena ʻē aʻe. No laila, hiki ke hoʻohana ʻia i nā maʻi cardiovascular a me nā ʻōnaehana nerve. Ua hoʻonui ka nānā ʻana i kāna mau noiʻi ākea a koʻikoʻi. Wahi a ka noiʻi hou loa, he hopena maikaʻi ka berberine i ka pale ʻana a me ka mālama ʻana i ka hypertension, hyperlipidemia, diabetes, arrhythmia, tumors a me nā maʻi ʻē aʻe. Ua hōʻike nui ʻia ka Berberine hydrochloride i ka hoʻēmi ʻana i nā lipids koko. Hiki i ka BBR ke hoʻoponopono i ka hōʻike ʻana o ka lipoprotein receptor haʻahaʻa haʻahaʻa LDLR a hoʻoikaika i ka lawe ʻana o ka protein LDL e nā pūnaʻi ate. Hoʻololi ʻia ʻo BBR i dihydroberberine (dhBBR) e ka nitroreductase o ka intestinal flora gut microbiota, e maʻalahi ia e komo i ka ʻōpū. Ma hope o ka absorption, ua oxidized ia i BBR i loko o ka ʻiʻo ʻōpū a komo i ke koko. Loaʻa i nā hopena hoʻohaʻahaʻa lipid a me nā hopena hypoglycemic. Hiki i ka BBR ke hoʻomaikaʻi i ka metabolism ikehu. ʻO ka hoʻoponopono waha o BBR e koi i ka microbiota o ka ʻōpū e hana i ka butyrate, e komo ana i ke koko a hana i nā SCFA (nā ʻakika momona kaulahao), e hōʻemi ana i nā lipids koko a me ke kō koko.
Hiki i ka BBR ke hoʻoikaika i ka hoʻolaʻa hou ʻana o nā cell islet pancreatic a ʻoi aku ka maikaʻi ma mua o nā lāʻau lapaʻau anti-diabetic. Ua hōʻoia nā hoʻokolohua pili pili i ka berberine hiki ke kāohi i ka myocardial fibrosis i nā ʻiole maʻi maʻi; Loaʻa i ka BBR nā hopena anti-platelet, hiki ke hoʻonui i ka ʻike nucleotide i loko o nā platelets a ke kāohi i ka aggregation. ʻO ka Berberine i hui pū ʻia me nā statins he kuleana koʻikoʻi i ka hoʻopaʻa ʻana i ka trimethylamine oxidation plasma i ka maʻi naʻau coronary a me ka pale ʻana i ka hoʻokumu ʻana o ka atherosclerosis.
ʻO ka berberine Kina kahi koho kūpono i nā lāʻau "statin". No ka mea ʻoi aku ka maikaʻi o ka berberine ma mua o nā lāʻau "statins", ʻo ka loaʻa ʻana o ka hopena hoʻohaʻahaʻa i ke koko-lipid-lowering o berberine he waiwai ʻole no ka pale ʻana a me ka mālama ʻana i ka hyperlipidemia, ka maʻi diabetes a me ka maʻi cardiovascular.
【kāhea iā mā˚ou】
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Ka manawa hoʻouna: Jan-08-2024
