Liposome NMN–he mole NMN i hoʻopaʻa ʻia me ka ʻoi aku ka maikaʻi o ka absorption

Manaʻo ʻia ʻo NMN ka mea maikaʻi loaNAD+ mua i loko o ke kino kanaka. Eia naʻe, manaʻo ka poʻe ʻepekema conservative hiki ke kaupalena ʻia ka absorption o NMN i kekahi ʻano. Ma ka hoʻohui wale ʻana i nā kau nui o NMN hiki ke loaʻa kahi hopena hoʻololi kūpono.
I kēia hopena, ua hoʻomohala maikaʻi ʻo Bangtai i ka liposomeNMN, ka escort express o NMN, a hoʻomaka i ka hana nui nui.
He ahaliposomes NMN ? E nānā mua kākou i nā liposomes?
ʻO nā liposome nā vesicles i hana ʻia me nā molekole phospholipid - nā molekole like i hana i nā membrane cell.
ʻO nā molekole Phospholipid kahi poʻo phosphate hydrophilic a me ʻelua huelo waika momona hydrophobic. Hoʻolilo kēia mau hiʻohiʻona i nā liposomes i mea lawe no nā pūhui hydrophobic a me hydrophilic.

Ma muli o ka haʻahaʻa haʻahaʻa a me ka bioavailability o nā capsules meaʻai kuʻuna waha, ʻo ka encapsulation o ka hydrophilic a me nā meaʻai hydrophobic i loko o nā liposomes e hiki ai i nā mea hana ke kāpae i ka luku ʻana i ka ʻōnaehana gastric.
No ka hoʻokuʻu ʻana i nā molekala i hoʻopaʻa ʻia i ke kahua o ka hana, hui pū ka lipid bilayer me nā bilayer ʻē aʻe (e laʻa, nā membrane cell), hāʻawi pololei i nā mea liposomal a paʻa i loko o nā cell a me nā ʻiʻo.
No ka maʻalahi, ua like nā liposomes me kahi kaʻa kaʻa kaʻa kālā nui, e pale ana i ke "kālā (lāʻau lapaʻau)" i loko o ke kaʻa mai ka ʻaihue ʻia ma ke ala i ke ake a me nā mea ʻē aʻe.
ʻO ka ʻoiaʻiʻo, ua loaʻa i nā huahana liposome kekahi mau moʻolelo kūleʻa. Hoʻohana kekahi poʻe i nā liposomes e hoʻopili iā Fisetin, a hoʻonui ʻia ka bioavailability i 27 mau manawa; ʻO ka bioavailability o ka liposomal vitamin B-12 formula he 3-5 mau manawa kiʻekiʻe ma mua o nā papa; Hiki i ka liposomal berberine ke hoʻonui i ka manawa holo 23-46 manawa.
No laila, he mea pono e encapsulateNMNi loko o nā liposomes?
Ma ka hoʻoholo ʻana mai ke ʻano o ka hana i hoʻopaʻa ʻia, hilinaʻi ʻo NMN i ka transporter slc12a8 ma nā ʻōpū liʻiliʻi e lawe iā ia i loko o nā pūnaewele, a laila hoʻonui i nā pae NAD + i nā ʻāpana like ʻole a me nā ʻiʻo o ke kino i ke kahe ʻana o ke koko.
Eia nō naʻe, hiki ke hoʻohaʻahaʻa ʻia ka NMN i ka wā e hiki ai ka makū a me ka mahana i kahi kiʻekiʻe. I kēia manawa, ʻo ka hapa nui o NMN ma ka mākeke ma ke ʻano o nā capsules a me nā papa. Ma hope o ka lawe ʻana i nā capsules NMN a i ʻole nā ​​​​papa, ua hoʻohaʻahaʻa ʻia ka hapa nui o lākou i ka ʻōpū. ʻO kahi hapa liʻiliʻi wale nō o NMN e hiki i ka ʻōpū liʻiliʻi, ʻo ia ka hapalua o ka hopena me ka ʻelua o ka hoʻoikaika ʻana.
Ma hope o ka hoʻopili ʻia ʻana o NMN e nā liposomes, hiki ke pale ʻia ka NMN a hiki i ka wahi i kuhikuhi ʻia.
ʻO ka mea mua, hiki i ka liposomal NMN ke kāpae i ka hōʻino ʻana o ka ʻōnaehana digestive, e ʻae iā ia e komo pololei i ke kahe koko a hiki i nā ʻano o ke kino.
ʻO ka lua, hoʻokuʻu ka liposomal NMN i nā molekala NMN ma o ka hui ʻana o ka membrane, kahi e hoʻopaneʻe ai i ka hoʻomaʻemaʻe ʻana o nā molekala NMN a hoʻonui i ko lākou manawa kaʻa i loko o nā kīʻaha koko, e hōʻemi ana i nā macrophages i loko o ka ʻōnaehana reticuloendothelial (RES) i ka liposomal NMN. ʻO ka ʻai ʻana, a hoʻomaikaʻi i ka pae paʻa o nā molekala NMN.
Eia kekahi, ʻo ka NMN i hoʻopaʻa ʻia i loko o nā liposomes e pale i ka metabolism, a ʻo nā molekala lāʻau e hana wale ana ma hope o ka hōʻea ʻana i kahi kahua i hoʻokuʻu ʻia a hoʻokuʻu ʻia mai nā liposomes.
I ka hopena, ʻo ka liposomal NMN kahi ala maikaʻi e pale ai i ka hoʻohaʻahaʻa ʻana o NMN i ka ʻōnaehana gastric.

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