Berberine hydrochloride

Loaʻa iā ia nā hopena inhibitory ma Escherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi a me amoeba. Ma ke kino, hoʻohana nui ʻia e luku i nā maʻi a me nā maʻi bacteria. Ua ʻike ʻia he hopena anti-arrhythmic kēia huahana. Loaʻa i ka Berberine ka hana anti-tumor in vitro a hiki ke hoʻoulu i ka huna ʻana o nā cell B16; like me ka cytarabinehydrochlorideHe hopena maikaʻi kona in vitro.

Ke kumu
He alkaloid isoquinoline. Huina molekiko [C20H18NO4]+. ʻIke pū ʻia he berberine. Aia i loko o nā mea kanu he 10 genera a me 4 ʻohana me Berberidaceae. Hiki i ka Berberine ke hoʻoheheʻe i nā kristal like me ka nila melemele mai diethyl ether. Ka helu hehee 145 ℃. Hiki ke hoʻoheheʻe ʻia i ka wai, ʻaʻole hiki ke hoʻoheheʻe ʻia i loko o ka benzene, ka etera a me ka chloroform. ʻO Berberine kahi alkaloid ammonium quaternary, a he liʻiliʻi ka solubility o kāna mau paʻakai i ka wai, no ka laʻana, he 1:500 ka hydrochloride a ʻo ka sulfate he 1:30. ʻO nā kristal o ka berberine i hoʻokahe ʻia mai ka wai a i ʻole ka ethanol dilute he 5.5 mau molekala o ka wai aniani; inā i hoʻoheheʻe ʻia mai ka chloroform, acetone a i ʻole benzene, loaʻa pū kekahi i nā molekole hoʻoheheʻe crystallization. Hiki ke mālama ʻia ka Berberine me nā alkali like ʻole e loaʻa ai ʻekolu ʻano ʻano berberine: ʻano ammonium quaternary, ʻano aldehyde a me nā ʻano waiʻona, ma waena o ka ʻano ammonium quaternary ka mea paʻa loa. ʻO Berberine ka hopena antibacterial ma ka hemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freundii a me Shigella dysenteriae, a hoʻonui i ka phagocytosis o ke koko keʻokeʻo. Ua hoʻohana nui ʻia ka Berberine hydrochloride (ʻike nui ʻia ʻo berberine hydrochloride) e mālama i ka gastroenteritis, bacillary dysentery, etc., a loaʻa pū kekahi mau hopena i ka maʻi maʻi, ka ʻulaʻula, ka tonsillitis a me nā maʻi hanu.

lāʻau lapaʻau
pharmacodynamics
Loaʻa iā ia kahi ākea antibacterial ākea a loaʻa nā hopena antibacterial ma nā ʻano bacteria Gram-positive a -negative in vitro, me ka hemolytic Streptococcus, Staphylococcus aureus, a me Vibrio cholerae. ʻO ka Meningococci, Shigella dysenteriae, Typhoid bacilli, Diphtheria bacilli, a me nā mea ʻē aʻe he mau hopena paʻa ikaika. He bacteriostatic lākou ma nā haʻahaʻa haʻahaʻa a me ka sterilizing ma nā kiʻekiʻe kiʻekiʻe. Loaʻa iā ia kekahi mau hopena pale i nā maʻi influenza, amoeba, leptospira, a me kekahi mau ili ili. Ua hōʻoia nā hoʻokolohua in vitro hiki i ka berberine ke hoʻonui i ka hiki phagocytic o nā leukocytes a me ka ʻōnaehana reticuloendothelial ate. ʻO Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, a me nā mea'ē aʻe he maʻalahi ke kū'ē i kēia huahana. ʻAʻohe kūʻē kūʻē ma waena o kēia huahana a me ka penicillin a me ka streptomycin.

Pharmacokinetics
ʻAʻohe o ka waha waha. Ma hope o ka hoʻopiʻi ʻana, komo koke ia i nā ʻāpana like ʻole a me nā ʻiʻo, a mālama ʻia ke koko no ka manawa pōkole. ʻOi aku ka haʻahaʻa o ke koko ma hope o ka intramuscular injection ma mua o ka palena haʻahaʻa. Hoʻolaha nui ʻia ka lāʻau lapaʻau, ʻo ka hapa nui ma ka puʻuwai, iwi, akemāmā a me ke ake. He pōkole ka manawa paʻa i loko o nā ʻiʻo, a he hapa wale nō i koe ma hope o 24 mau hola. ʻO ka hapa nui o nā lāʻau lapaʻau e metabolized a hoʻopau ʻia i loko o ke kino, a ʻoi aku ka liʻiliʻi ma mua o 5% o ka dosis i hoʻoponopono ʻia i hoʻokuʻu ʻia ma ke ʻano kumu i loko o 48 mau hola.
Wahi a nā hōʻike hou, manaʻoʻiʻo hiki i kēia huahana ke hoʻemi i ka helu o nā pili ma luna o ka ʻili o ka maʻi bacteria, e pale ana i ka maʻi bacteria mai ka hoʻopili ʻana i nā cell kanaka, a he hopena therapeutic. He hopena nō hoʻi kēia huahana i ka Helicobacter a hiki ke hoʻohaʻahaʻa i ka gastritis, ka ʻōpū a me ka ʻeha duodenal.

Hoʻopau ʻia a hoʻohana ʻia me ka akahele
ʻOiai hiki ke hoʻohana ʻia i nā keiki, ua ʻae ʻia ia i nā keiki me ka hemahema o ka glucose-6-phosphate dehydrogenase no ka mea hiki i kēia huahana ke hana i ka anemia hemolytic a alakaʻi i ka jaundice.

Nā hopena ʻino
(1) He kakaikahi ka hopena o ka waha, me ka nausea, ka lua'i, ka ma'i a me ke kuni lā'au, e nalowale ana ma hope o ka pau 'ana o ka lā'au.
(2) Hiki ke hoʻoulu ʻia nā hopena e like me ka vasodilation, hāʻule ke koko, a me ka puʻuwai puʻuwai. I nā hihia koʻikoʻi, hiki ke loaʻa ka maʻi Aspen, a me ka make. Ua hoʻolaha aku ʻo Kina i ka hoʻopau ʻia ʻana o nā injections like ʻole o ka berberine hydrochloride.
Loaʻa i kekahi poʻe ka ʻoluʻolu ʻole o ka ʻōpū a i ʻole ka ʻōpū, constipation a i ʻole ka maʻi maʻi.

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